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Description
Introduction to Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension (PAH) is a progressive type of high blood pressure that occurs when the small blood vessels in the lungs get narrow which blocks and destroys them.
This condition increases the resistance of blood to the stream, making the blood flow difficult through those arteries. In short, when the blood pressure is high in the lungs, it is known as pulmonary hypertension.
In such conditions, the heart has to work harder and pump blood in the vessels which can result in heart failure. Pulmonary Arterial Hypertension can happen to people at any age, but it is most likely to be diagnosed in people aged between 30-60 years and is more common in women.
The condition diagnosed in older men is possibly to have more severe cases. There is no cure to recover PAH. However, there are several ways to manage the symptoms and slow down the progression of pulmonary hypertension.
Overview of Assurans
As there is no proper cure to recover from pulmonary arterial hypertension, there are many ways to maintain the condition to prevent symptoms and the progression of the condition. One of the commonly prescribed medicines used to treat pulmonary arterial hypertension is Assurans 20 mg.
Assurans 20 mg is a medication used to help maintain elevated blood pressure in the arteries that supply blood to the lungs (pulmonary arterial hypertension).
The active ingredient of Assurans 20 mg is Sildenafil Citrate which is commonly most used drug for sexual dysfunction in men. It belongs to a class of medicines known as PDE-5 inhibitors.
As you know Assurans 20 mg contains Sildenafil Citrate, which has been scientifically confirmed as a treatment of high blood pressure in the blood vessels in the lungs.
The treatment of Sildenafil aims to improve the ability to exercise and avert the progression of pulmonary arterial hypertension. This drug has significantly reduced high blood pressure under resting conditions as well as while exercising.
Efficacy of Assurans in PAH Treatment
The key component in Assurans 20 mg, Sildenafil was primarily examined for the use of high blood pressure (pulmonary hypertension) and angina pectoris.
The initial clinical trials were managed at Morrison Hospital in Swansea. Phase I clinical trials under the supervision of Ian Osterloh implied the drug had slight efficacy on angina, but it could produce prominent penile erections.
One of the most trusted pharmaceutical companies therefore decided to promote it for erectile dysfunction, rather than marketing it for angina.
This conclusion became a quoted example of drug repositioning. Thus, the drug was licensed in 1996 and approved by the FDA on 27th March 1998.
In patients with collagenosis who have an irregular hemodynamic response to exercise, sildenafil enhanced alteration of the right ventricular-pulmonary vascular unit to exercise liberated.
The drug improves hemodynamic parameters at rest and while exercising. But, it also carries the chance of aggravating arterial ventilation, especially at rest.
Three months of Assurans 20 mg therapy in adults was well accepted and related with remarkable improvements.
Sildenafil enhances hemodynamics and functional capacity in pulmonary arterial hypertension.
How to use it?
Assurans 20 mg comes in a blue-colored tablet meant to be taken orally, by mouth. This medicine is intended to be gulped with a glassful of water. Swallow it as a whole. Chewing, crushing, or splitting it in half would affect its ability to work.
The tablet may be taken with food or on an empty stomach. But, you will get a better outcome if you take the medicine at a fixed time every day. Do not take this medicine once it has passed its expiration date. Dispose of the expired pack and purchase a new one to continue the treatment.
How does it work?
Assurans 20 mg is a phosphodiesterase type-5 inhibitor that helps in treating pulmonary arterial hypertension, a condition where blood in the arteries faces difficulty to flow smoothly leading to high blood pressure in the lungs.
It works by calming the blood vessels in your lungs resulting in normal pressure of the blood in the lungs. This permits your heart to work less in pumping the blood to your lungs.
Dosage and Administration of Assurans in PAH
The dose and duration of Assurans 20 mg is settled by the doctor after examining your condition. The doses and power of the medication are decided based on age, body weight, severity of condition, and other health concerns.
Follow the prescription and other instructions advised by your doctor to make sure you attain the maximum benefits of the medicine.
Do not change the treatment to something that is based on your needs without referring the medics beforehand.
Consuming excess or stopping the medicine would cause undesirable side effects and withdrawal symptoms.
Do not cease the medication even when you begin to feel better and complete the treatment. Do not add any other medicines or replace this with another drug without your doctor’s agreement.
If you have missed a dose of this drug, take it right away. However, if it is already time for another dose of the same medicine you must avoid taking that missed dose and stick to your regular schedule.
Overdosing on the medicine would not help you recover faster or gain extra benefits. Instead, it will make your health much worse as there will be double the amount of drugs in your body. Stay away from overdose and call the healthcare department if you may have mistakenly taken excess pills.
Administration Routes
The dosage of Assurans 20 mg depends on the route of administrating the medicine. You get two administration routes for the treatment of this drug, oral and intravenous. The route of administrating the medication depends not only on your convenience but also on drug properties and pharmacokinetics.
Considerations for Special Populations
There are special populations for which you must consider consulting a doctor.
Pregnant Women
The drug this medicine entails, Sildenafil is intended to be used by men primarily. Consult the doctor to know about the potential risks and benefits before exercising the medicine.
Breastfeeding Women
As the drug is created for men’s use; this medicine may be harmful to the nursing baby. Talk to your doctor and get an appropriate treatment for your sexual dysfunction.
Pediatrics
The drug this medicine contains is not approved for the use of children below the age of 18 years. Consult your doctor before starting this treatment.
Geriatrics
This medicine should be used with caution in elderly patients. Talk to your doctor and know more about the safety and effectiveness of the medicine before use.
Adverse Effects
Common Adverse Reactions
Taking Assurans 20 mg treatment may have a few negative effects that probably do not need any medical attention. It recovers on its own once the patient’s body has fully developed the change or when the treatment is complete. Do visit your doctor if these effects bother you or get worse.
- Nasal congestion
- Altered vision
- Feeling dizzy
- Problems with digestion
- Muscle ache
- Diarrhea
- Bleeding through nose
- Sneezing
- Trouble sleeping
- Runny nose
- Redness of the skin
- Facial flushing
- Headache
- Labored breath
- Prolonged erection
Monitoring and Management of Side Effects
To maintain pressure on the blood in your arteries, it is crucial to manage it and take certain medications. You may observe some common side effects listed above that you can manage by taking a few precautions.
Dizziness & drowsiness
You should rest more often and relax. Get proper sleep. Avert driving and using any heavy tools or machinery totally during the treatment of this medicine. Do not consume excess alcohol as it can elevate your lightheadedness. Visit the doctor if your dizziness worsens with time.
Headache
Frequently rest and de-stress. Drink more water or electrolytes to keep you hydrated by drinking these fluids. Use a pain-relieving ointment on your forehead as it can be beneficial during your headache. Avoid drinking excessive alcohol as it can provoke your headache. Talk to your doctor and get a solution if the headache continues.
Nausea & vomiting
Take the medicine with or right after your complete meal. Eat simple light meals. Avoid having fried, spicy, and oil-rich foods. Refer to your doctor if your nausea gets worse.
Contraindications and Precautions
Alcohol
You may perceive some side effects after this medicine like dizziness and sleepiness. Drinking alcohol can enhance the intensity of those effects.
Driving
Due to being lightheaded and drowsy, don’t do anything that requires your complete attention and focus like driving and using any heavy tools. It can be risky for your health.
Allergy
Do not begin the treatment of Assurans 20 mg if you are allergic to Sildenafil Citrate. You can instead ask for an alternative treatment.
Other medical conditions
Talk about your medical history and health concerns you may have now like high blood pressure, blood sugar levels, cholesterol, heart health, or any other disease associated with any organ. Also, discuss its medical treatments.
Potential Benefits and Risks
Benefits of Assurans 20 mg are:
- It is one of the most effective medicines used to treat pulmonary hypertension and erectile dysfunction in men.
- Another benefit of this medicine is how simple it is to get. Purchasing Assurans online has become easy by Arrowmeds Pharmacy at an affordable Assurans price of $87 pack of 60 tablets.
- It contains a fast-acting ingredient that has an onset of 30 to 60 minutes. Because of this, it is an effective option for those who need rapid solutions.
Risks of Assurans 20 mg are:
- The possibility of severe effects you may get from the medicine is the main risk. You may see a few common side effects that are to worry about. But, some adverse effects like vision impairment and hearing loss might also happen.
- Interaction between the medicine and another drug may have some serious negative effects. For example, you may experience a huge drop in your blood pressure when sildenafil (the active agent of this medicine) and nitrates interact.
- It may not be suitable for everyone. In some health conditions or some people, the medicine may act differently and give according to reactions.
Conclusion
Assurans tablet is used to treat high pressure of the blood in the arteries that take the blood from the heart to the lungs which is known as pulmonary arterial hypertension. A normal blood pressure can improve your quality of life and ability to exercise.
Do not add any extra drugs in your treatment like nitrates or nitroglycerin with this medication as it could drop your blood pressure to an unsafe level. Cease the tablet and contact your doctor right away if your vision is affected in one or both eyes or notice sudden hearing loss. Do not suddenly discontinue the medication without the doctor’s agreement as it could worsen your condition and cause withdrawal symptoms.
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