Progynon Depot

Progynon Depot (Generic) (Estradiol Valerate)

(1 customer review)
Active Ingredient (Generic Name): Estradiol Valerate
Indication: Hormone replacement therapy
Manufacturer: Actiza Pharmaceutical Pvt. Ltd.
Packaging: 10 x 1 ml in 1 vial in box
Strength: 10mg
Delivery Time: 6 To 15 days
10% OFF: Use Code AM10 @ Checkout page

Progynon Depot (Generic) (Estradiol Valerate) - 10mg

10mg Price Price/unit Quantity Add To Cart
10 Ampoule/s $15 $1.5 /Ampoule
20 Ampoule/s $25 $1.25 /Ampoule
30 Ampoule/s $30 $1 /Ampoule
40 Ampoule/s $39 $0.98 /Ampoule
50 Ampoule/s $48 $0.96 /Ampoule
60 Ampoule/s $55 $0.92 /Ampoule
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Last Updated on
Medically Reviewed by
Dr. Olivia Nelson

What Our Customer Says


Progynon Depot (Generic) USA is a popular Hormone Replacement Therapy. It has helped numerous females recover from symptoms associated with menopause. Also, it is a former medication for treating osteoporosis and bridging the gap of Estrogen deficiency. If you are prescribed this injection and want to buy the same in the USA, could be the best online pharmacy to make your purchase. Before you proceed, have a look at all the details about this medicine.

Overview of Progynon Depot

What is Progynon Depot Injection?

Progynon Depot is nothing but an injection containing Estradiol Valerate as the major active ingredient. It mimics Estrogen, the female sex hormone.

This injection is mainly used for treating menopause-related symptoms like vaginal dryness, itchiness, and hot flashes. Moreover, it is suggested to fulfill Estrogen deficiency among women and improve bone-thinning (aka osteoporosis).

Active ingredient: Estradiol Valerate

Estradiol Valerate is the major content of this injection and it is the synthetic form of Estrogen. As shared above, it mimics the naturally occurring female sex hormone. It helps in relieving symptoms experienced after menopause in women – hot flashes, itchiness, and vaginal dryness. It contributes towards improving the overall quality of life among women undergoing hormonal changes after menopause.

Uses of Progynon Depot

Below are the major prescription uses of this injection. Make sure you use it only if prescribed by a healthcare provider.

Managing post-menopausal symptoms (hot flashes, vaginal dryness & itching)
Treatment for Estrogen deficiency
Osteoporosis (bone-thinning)

How does it work?

Estradiol Valerate, the key ingredient of this injection, works by supplying the required amount of Estrogen to the female body. As a result, the ongoing hormonal changes among post-menopausal women can be balanced easily.

It also alleviates symptoms among post-menopausal women like vaginal dryness, hot flashes, itchiness, etc. By mimicking the naturally occurring Estrogen, this injection allows women to lead an improved quality of life amidst the changes happening internally.

This injection should be applied by a medical professional only. It has certain benefits and risks associated. Thus, the side effects and interactions should be understood before proceeding with the treatment.

Recommended dosages for different conditions

As discussed earlier, Progynon Depot injection is prescribed for varied purposes. Hence, the recommended dosage will likely be different according to the underlying symptoms to address.

Post-Menopausal Symptoms

Beginner dose – Initially, this injection can be suggested in 10 mg or 20 mg strengths for observing the effects of Estradiol Valerate on the patient. It can be injected intramuscularly in a gap of 1 to 4 weeks.

Maintenance dose – Once the treatment begins and the response goes as expected, the dosage can be reduced to 1 to 5 mg to retain the effectiveness of Estradiol Valerate in the body. The frequency of injection can vary between 1 to 4 weeks.

HRT (Hormone Replacement Therapy)

Beginner dose – For HRT, the dosage remains 10 mg or 20 mg depending on the underlying symptoms. Progynon Depot can be injected every 1 to 4 weeks intramuscularly to improve the symptoms.

Maintenance dose – This injection can be applied at an interval of 1 to 4 weeks, depending on the individual’s response towards treatment, for maintaining effectiveness. The healthcare provider will determine the frequency of dosage based on the individual’s requirements and response respectively.

Available Strengths of Progynon Depot

Medical conditions or situations where Estradiol Valerate should not be used

Estradiol Valerate is not advised for use during certain circumstances or medical conditions. They are as below:

  1. Hypersensitivity: Females allergic to Estradiol Valerate or those developing hypersensitivity towards this medication immediately upon usage should not take it anymore.
  2. Breast Cancer: Women having a history of breast cancer or those diagnosed with breast cancer recently should avoid this injection because of its estrogenic effects. This medication is found to promote the growth of several types of breast cancer cells.
  3. Pregnancy: The active ingredient of this injection can cause fetal harm. Hence, it should not be administered among pregnant women. Similarly, seek medical guidance if you are about to apply it while breastfeeding.
  4. Liver impairment: Women having severe liver disorders or impaired liver functions should avoid using this injection. It can lead to hepatic dysfunction and increase the risk of adversities.
  5. Vaginal bleeding (undiagnosed): It is restricted for use among women who get undiagnosed vaginal bleeds. Report such symptoms to the healthcare provider before the issue gets serious.
  6. Tumours dependent on Estrogen: Females having a history of endometrial cancer or uterine fibroids may undergo health issues by using this injection. Inform the healthcare provider beforehand if you have these problems.
  7. Thromboembolic disorders: Patients with a history of Thromboembolic disorders (like deep vein thrombosis or pulmonary embolism) should avoid this injection. It can contribute to an increase in the risk of Thromboembolic events.

Risks/Adverse Effects

The adverse reactions of Progynon Depot injection can be broadly categorized as common and rare. Below are they listed for your reference. Seek medical guidance whenever the symptoms persist or have no signs of improvement.

Common side effects

These are temporary reactions that are supposed to appear while your body is adjusting to the ingredients of this injection. Once the body gets friendly to the medication, it shall disappear.

  • Nausea
  • Vomiting
  • Headache
  • Changes in menstrual cycle
  • Tenderness of breasts
  • Mood changes
  • Fluid retention

Rare but serious adverse reactions

Below are the adverse reactions that need immediate medical attention.

  • Risk of breast cancer
  • Allergic reactions on the skin
  • Changes in libido
  • Gastrointestinal disturbances
  • Fatigue
  • Dizziness
  • Thromboembolic events

Special considerations, Precautions & Safety Warnings

  • You may buy Progynon Depot online but don’t apply it yourself. It should be injected by a medical professional only.
  • Don’t use this injection during pregnancy or breastfeeding due to associated risks on the fetus and breastfeeding child.
  • Progynon Depot injection may exacerbate medical conditions like breast or endometrial cancer. Such patients should use this injection cautiously and only after disclosing them to the healthcare provider.
  • The main ingredient of this injection may increase the risk of blood clots, heart attack, or stroke. Hence, inform your doctor if you have had a heart attack in the past six months, or have severe cardiovascular issues already.
  • Women with liver impairment or hypercalcemia should use this medication with utmost caution.
  • This injection may increase the risk of endometrial hyperplasia and gallbladder disease. If you already suffer from such health issues.
  • Using Progynon can lead to fluid retention commonly among individuals with migraine, epilepsy, asthma, or renal dysfunction. Close monitoring is required during such instances.
  • Do not use this injection while having its contradicting medicines such as anticonvulsants, antibiotics, or herbal supplements. Inform your doctor about the medicines you are using already, be it any vitamin or dietary supplement.

Progynon Depot Price

As you buy Progynon Depot online with, you get it at the best prices. The price starts at $15 for 10 ampoules. That is just $1.5 per piece, a deal you should not miss! It is for 10 mg strength. Get the benefit of a 10% discount using code AM10 instantly as you shop it with us. We’ll ensure your order reaches you faster with 100% guaranteed quality medication.


Progynon Depot (Generic) Injection is a valuable treatment as Hormone Replacement Therapy. Over the years, it has been improving millions of lives by enhancing symptoms post-menopause, fulfilling Estrogen deficiency, and eliminating osteoporosis. It emerges as a legitimate solution for elevating the overall quality of well-being among suffering females. You, too, can improve your quality of life with Progynon Depot Injection by ensuring high-quality purchases with reliable sources like Consult your healthcare provider today & order your stash!


Can Progynon Depot be taken with food?

This injection can be taken with or without food. For any such queries, seek medical guidance and understand its interactions with food.

Is Progynon Depot safe to use during pregnancy and breastfeeding?

No, it is regarded as unsafe during pregnancy and breastfeeding. It can cause potential harm to the fetus developing in the womb and affects the child having breast milk. Inform your healthcare provider if you are pregnant or breastfeeding and being prescribed this injection.

What should I do if I miss a dose of Progynon Depot?

Seek medical guidance regarding missed dosages. Your healthcare provider will share when to catch up on the missed dosages depending on how much time has passed after you missed the suggested dose. They shall adjust your dosage schedule accordingly. Meanwhile, you can try not to skip or miss dosages otherwise it can affect your overall treatment schedule.

How to store Progynon Depot Injection?

It can be stored at normal room temperature and away from direct sunlight, heat, or moisture. Make sure it isn’t placed at easy access to children and pets. Once used, discard it according to the guidelines mentioned on the product packaging. Don’t throw it away anywhere or flush it in the toilet.

Is Progynon Depot safe for children?

It is typically unsafe for use among children. Paediatric use may be suggested in selected cases only. However, don’t administer it among children without medical guidance.

1 review for Progynon Depot (Generic) (Estradiol Valerate)

  1. bhoomfashion4

    recived package within 6 days…speedily deivery

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