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Alternative Medicine
Pazopanib 400 mg (Generic)
Just $7.43 /Sachet View Detail This product has multiple variants. The options may be chosen on the product page
Pazopanib 200 mg (Generic)
Just $3.61 /Tablet View Detail This product has multiple variants. The options may be chosen on the product page
Votrient 200 mg (Pazopanib)
Just $3.61 /Tablet View Detail This product has multiple variants. The options may be chosen on the product page
Description
What is Votrient 400 mg?
Votrient 400 mg is an oral anti-cancer medication prescribed for the treatment of kidney cancer (renal cell carcinoma) and advanced soft tissue sarcoma. It contains Pazopanib, a tyrosine kinase inhibitor that works by blocking certain enzymes responsible for cancer cell growth, ultimately helping to stop or slow the spread of tumours.
Kidney cancer occurs when abnormal cells begin to grow in the kidney, although not all growths are cancerous. Renal cell carcinoma is the most common type in adults, often presenting with symptoms such as fatigue, sudden weight loss, blood in urine, loss of appetite, and persistent pain in the sides or back.
Votrient 400 mg is also effective in treating soft tissue sarcoma, a rare form of cancer that develops in the body’s soft tissues, including muscles, fat, nerves, blood vessels, tendons, and joint linings. This condition may occur in various parts of the body, but commonly affects the arms, legs, and abdominal area.
Uses of Votrient 400 mg
Treatment of Kidney Cancer (Renal Cell Carcinoma)
- Used in adults to manage advanced renal cell carcinoma by slowing tumour growth and helping restrict cancer spread.
Management of Advanced Soft Tissue Sarcoma
- Prescribed for patients who have previously received other cancer treatments but did not respond adequately.
- Helps inhibit the growth of cancer cells in soft tissues such as muscles, fat, nerves, blood vessels, and tendons.
Targets Tumour Growth Pathways
- Contains Pazopanib, a tyrosine kinase inhibitor that blocks specific proteins responsible for cancer cell growth and survival.
Used When Other Therapies Fail or Are Not Suitable
- Often recommended in cases where standard chemotherapy or treatments are not effective or appropriate.
Mechanism of Action
The active ingredient of the Votrient 400 mg, Pazopanib, starts showing it works by reducing the blood supply, especially to the cancer tumor, for slowing down its growth.
Dosage and Administration
The dose is recommended once a day without food (or you may take the dose an hour before a meal or a couple of hours before a meal)
- First dose reduction: 400 mg orally once a day
- Second dose reduction: 200 mg orally once a day
For soft tissue sarcoma:
- First dose reduction: 600 mg orally once a day
- Second dose reduction: 400 mg orally once a day
NOTE: Permanently discontinue therapy in patients unable to tolerate the second dose reduction.
Indications
The Votrient is a type of kinase inhibitor used for treating advanced renal cell carcinoma and advanced soft tissue sarcoma, used before chemotherapy. Before checking for the Votrient 400 mg price, it is essential to thoroughly understand this medicine. However, it has limitations in terms of usage for treating adipocytic soft tissue sarcoma or even gastrointestinal stromal tumours that are not addressed.
Side effects
- Diarrhea
- Vomiting
- Nausea
- Headache
- Loss of Appetite
- Weight Loss
- Numbness
- Tingling Sensation
- Redness in Hands/feet
- Feeling of Weakness
- Temporary Hair Loss
- Change in Skin or Hair
- Swelling Feet/Ankles
- Unusual Weight Gain
- Slow Heartbeat
- Sore Throat
- Chills
- Cough
- Fever
Contraindications
- Fexinidazole
- Alemtuzumab
- Hydroxychloroquine
- Itraconazole
- Lemborexant
- Mifepristone
- Nizatidine
- Pacritinib
- Ranitidine
- Thioridazine
- Ziprasidone
- Amprenavir
Precautions and Warnings
- Inform your doctor about any sort of unusual allergic reaction to sorafenib, sunitinib, or pazopanib.
- During treatment, make sure to have your regular blood tests or blood pressure checked. On the basis of blood tests or pressure levels, your dosage may be changed.
- Try taking this medicine on an empty stomach.
- You should not chew, crush, or split this tablet. Just swallow the whole tablet.
- Try avoiding grapefruit juice till the time your treatment is complete.
- If you consume alcohol, then try taking it in small amounts. Consuming alcohol in large quantities can affect the effectiveness of Pazopanib.
- There is a huge chance that Pazopanib may start to damage sperm count and even harm the baby if used during pregnancy.
- This tablet must be stored safely in a container away from the reach of children at room temperature.
- The CYP3A4 Inhibitors must be avoided as they are potent inhibitors. There is a high chance that the doctor may decrease the dosage if administered with potent CYP3A4 inhibitors.
Conclusion
Votrient 400 mg is an effective protein kinase inhibitor used for kidney cancer and soft tissue sarcoma. It may cause side effects like high blood pressure, diarrhoea, and reduced blood cells, so regular monitoring is essential. Report symptoms such as fever, breathing issues, or flu-like signs to your doctor. Inform your doctor about any liver, kidney, or heart problems. You can also check its price online before buying.
FAQs:
What to Do in Case of a Missed Dose?
If you missed the Votrient 400 mg, try taking it as early as possible, that is, within 12 hours of the dose you missed. If the time exceeds more than 12 hours from the moment you miss the dose, then skip the last one and regularise your dosing schedule.
How do I take Votrient 400 mg?
Before starting to take the Votrient 400 mg, carefully go through the prescription. Take the Votrient 400 mg without food by mouth once a day. You need to take this medicine on an empty stomach. You can take it at least 1 hour before or after a couple of hours of a meal. You must swallow this medicine as a whole tablet. You should not chew, crush, or even break the tablet. If you do so, then it may release the necessary drugs or may lead to an increase in the side effects.
How does Votrient 400 mg work?
The tablet Votrient 400 mg is an anti-cancer medicine. It starts showing its working by first binding and then inhibiting the enzyme receptors, i.e., tyrosine kinase. It is responsible for the proliferation of cancerous cells. It starts to restrict new blood vessel growth within the tumour.
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