Description

Introduction

The Votrient 400 mg is a medicine for treating kidney cancer. This medicine is also prescribed by the doctor for treating advanced soft tissue sarcoma, especially in patients who recently received different cancer treatments. The active ingredient Pazopanib can also show its interference in the growth of cancer cells, which eventually get destroyed by the body. The medicine votrient 400 mg falls under the medicinal drug called tyrosine kinase inhibitors. The cells that start to grow in the kidney are known as kidney cancer. However, not all cells grown are cancerous. There are different tests to get the diagnosis done.

In adults, renal cell carcinoma is the most common kidney cancer. The symptoms that lead to kidney cancer are tiredness, extreme weight loss, blood in the urine, loss of appetite, and pain in the sides and back. On the other hand, the Votrient 400 mg is also recommended for Soft Tissue Sarcoma which is also a type of cancer but it’s a rare one. In this cancer type, the cells start to grow in the body’s soft tissues. The soft tissues such as blood vessels, tendons, nerves, muscle fat, and linings of the joints. The health condition of soft tissue sarcoma can take place anywhere in the body. It usually starts to happen in the legs, arms, and belly.

Indications

The Votrient is a type of kinase inhibitor used for treating advanced renal cell carcinoma and advanced soft tissue sarcoma used before chemotherapy. Before checking for the votrient 400 mg price it is essential to understand thoroughly about this medicine. However, it has limitations in terms of usage for treating adipocytic soft tissue sarcoma or even gastrointestinal stromal tumors that are not addressed.

Mechanism of Action

The active ingredient of the Votrient 400 mg i.e. Pazopanib starts showing it works by reducing the blood supply, especially to the cancer tumor for slowing down its growth.

Dosage and Administration

The dose is recommended once a day without food (or you may take the dose an hour before a meal or a couple of hours before a meal)

For urothelial carcinoma:

• First dose reduction: 400 mg orally once a day
• Second dose reduction: 200 mg orally once a day

For soft tissue sarcoma:

• First dose reduction: 600 mg orally once a day
• Second dose reduction: 400 mg orally once a day

NOTE: Permanently discontinue therapy in patients unable to tolerate the second dose reduction.

How do I take Votrient 400 mg?

Before starting taking the Votrient 400 mg carefully go through the prescription. Take the Votrient 400 mg without food by mouth once a day. It is essential for you to take this medicine on an empty stomach. You can take it at least 1 hour before or after a couple of hours of a meal. You must swallow this medicine as a whole tablet. You should not chew, crush, or even break the tablet. If you do so then it may release the necessary drugs or may lead to an increase in the side effects.

How does Votrient 400 mg work?

The tablet votrient 400 mg is an anti-cancer medicine. It starts showing its working by first binding and then inhibiting the enzyme receptors i.e. tyrosine kinase. It is responsible for the proliferation of cancerous cells. It starts to restrict new blood vessel growth within the tumor.

Side effects

• Diarrhea
• Vomiting
• Nausea
• Headache
• Loss of Appetite
• Weight Loss
• Numbness
• Tingling Sensation
• Redness in Hands/feet
• Feeling of Weakness
• Temporary Hair Loss
• Change in Skin or Hair
• Swelling Feet/Ankles
• Unusual Weight Gain
• Slow Heartbeat
• Sore Throat
• Chills
• Cough
• Fever

Contraindications

• Fexinidazole
• Alemtuzumab
• Hydroxychloroquine
• Itraconazole
• Lemborexant
• Mifepristone
• Nizatidine
• Pacritinib
• Ranitidine
• Thioridazine
• Ziprasidone
• Amprenavir

Precautions and Warnings

• Inform your doctor about any sort of unusual allergic reaction to sorafenib, sunitinib, or pazopanib.
• During the treatment make sure to get your regular blood tests or pressure level measured. As on the basis of blood tests or pressure levels your dosage may get changed.
• Try taking this medicine on an empty stomach.
• You should not chew, crush, or split this tablet. Just swallow the whole tablet.
• Try avoiding grapefruit juice till the time your treatment is going on.
• If you consume alcohol then try taking it in small amounts. Consuming alcohol in large quantities can affect the effectiveness of Pazopanib.
• There is huge chance that Pazopanib may start to damage sperm count and even harm the baby if used during the pregnancy.
• This tablet must be stored safely in a container away from the reach of the children at room temperature.
• The CYP3A4 Inhibitors must be avoided as it is a strong inhibitor. There is high chance that the doctor may decrease the dosage if administered with strong CYP3A4 inhibitors.

What to Do in Case of Missed Dose

If in case you missed the Votrient 400 mg, try taking it at the earliest that too within 12 hours of the dose you missed. If the time exceeds more than 12 hours the moment you miss the dose, then skip the last one and regularise your dosing schedule.

Conclusion

Overall, Votrient 400 mg is an effective medicine as it is a protein kinase inhibitor recommended for treating kidney cancer and soft tissue sarcoma. Although, a patient may start experiencing votrient 400 mg side effects such as high blood pressure and diarrhea. Regular monitoring of blood pressure levels while on the treatment must be done. You must drink plenty of fluids to overcome the diarrhea. There are huge chances of blood cells getting reduced in the blood.

If in case you start experiencing flu-like symptoms, fever, and difficulty breathing, and then inform the doctor at the earliest. If you ever have any kind of liver, kidney, or heart disease or are taking any kind of medicines for treating infection, inform the doctor. Before buying you can inquire votrient a 400 mg price in the USA from the Arrowmeds. There are huge chances you will get this medicine at the best price.

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