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Description
What is Combutol 400 mg
Combutol 400 mg is an antibiotic used to treat tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium tuberculosis. This disease affects the lungs and can also affect other parts of the body, such as the spine, brain, and kidneys.
It is available in tablet form and is an antituberculosis drug. Doctors prescribe this medicine alongside at least one other tuberculosis medicine to improve effectiveness and outcomes. This antibiotic tablet treats only bacterial infections and will not work for viral infections.
The active ingredient of this Combutol 400 tablet is Ethambutol, which disrupts the replication of Mycobacterium tuberculosis. Lupin Limited manufactures Combutol 400mg, driven by a strong commitment to advancing global healthcare.
Combutol 400 mg composition
Combutol contains 400 mg of Ethambutol hydrochloride as the active ingredient. Ethambutol prevents TB bacteria from multiplying and is used in combination with other antitubercular drugs for the treatment of tuberculosis.
Use of Combutol 400 mg tablet
Combutol 400 mg is given to those patients who are suffering from Tuberculosis. The doctor mainly prescribes this Combutol 400 tablet for the treatment of Tuberculosis affecting various organs, such as:
- Pulmonary Tuberculosis, which mainly affects the lungs
- Tuberculous meningitis that affects the membranes around the brain
- Abdominal Tuberculosis
- Urogenital Tuberculosis affects the kidneys and bladder
- Re-treatment of Tuberculosis in cases when previous treatments have failed
- Prophylactic therapy for preventing the development of Tuberculosis in high-risk individuals.
This medicine contains Ethambutol as its active ingredient, a bacteriostatic agent indicated, along with other essential medications such as isoniazid, rifampin, and pyrazinamide, for treating pulmonary Tuberculosis.
How to use Combutol Tablet?
Combutol 400mg comes as a tablet to take orally. Doctors usually advise taking it once a day and consuming it at the same time each day. You can take it with you without food, but take it at a fixed time. Don’t crush or chew the tablet; swallow it whole.
Patients need to follow the directions and dosage on their doctor’s prescription. Also, read the tablet leaflet instructions carefully. Don’t take more or stop the medication without consulting the doctor. The healthcare provider prescribes this medicine as a long-term medication and must be consumed daily.
What is the mechanism of action of Combutol 400 mg tablet?
Ethambutol is the main constituent of Combutol 400 mg tablet that works by stopping the growth of the bacteria that cause the disease. This medicine is the first-line tuberculosis treatment given to patients, along with other medications such as rifampicin, INH, and pyrazinamide. Ethambutol is a bacteriostatic drug that interferes with the biosynthesis of arabinogalactan in the cell wall. This ultimately helps in stopping the multiplication of bacilli.
Side effects of Combutol 400 mg
Patients may feel some mild side effects of Combutol 400, which will go away in a few days. Severe allergic reactions or side effects of this medicine are rare, but one should seek medical help immediately if any severe allergic reaction symptoms are observed. It is common to experience issues like nausea or headache when you are on this medication. Tell your doctor immediately if any of these effects last longer or get worse.
Common Side Effects of Combutol 400 mg:
- Headache
- nausea/vomiting
- upset stomach
- loss of appetite
- eye problems like inflammation of the optic nerve
Uncommon side effects:
- Hyperuricemia, Which Causes High Levels Of Uric Acid In The Blood
Rare Side effects:
- Numbness
- low blood platelet count
- Allergic reactions such as rashes, itching, and swollen, pale red bumps
- plaques (wheals) on the skin
Precautions and Warnings of Combutol 400 mg
- COMBUTOL 400mg is not given to pregnant women unless it is essential. So, it is advised to consult your doctor about your pregnancy or plans before taking it.
- Your doctor will give you the appropriate treatment after weighing the benefits and potential risks.
- Consult your doctor if you are a breastfeeding woman, as this tablet is generally not recommended.
- This antibiotic should be used with care in patients with kidney disease. A dose adjustment of Combutol 400mg may be needed. Consult your doctor, as kidney function tests are recommended for patients before starting the medication.
- Patients with liver problems should take Combutol 400 tablets cautiously. Please consult your doctor before taking it to get the correct dose.
- For paediatrics and geriatrics:
- Children below 13 years of age should not use Combustol 400 tablets. It should be used with caution in children above 13 years of age after analysing their health condition. Consult your doctor before taking, especially in paediatrics.
- Patients aged 65 or older should consult a doctor before taking Combutol 400 mg tablets. Your doctor will cautiously prescribe the correct dosage depending on your age and health condition.
- Don’t drive or operate machinery after taking Combutol 400 mg, as it may cause mild side effects such as disorientation, dizziness, or tingling/numbness.
- Don’t take COMBUTOL 400 mg if you are allergic to Ethambutol or any of the other components of this tablet.
Conclusion
- Children below 13 years of age should not use Combustol 400 tablets. It should be used with caution in children above 13 years of age after analysing their health condition. Consult your doctor before taking, especially in paediatrics.
- Patients aged 65 or older should consult a doctor before taking Combutol 400 mg tablets. Your doctor will cautiously prescribe the correct dosage depending on your age and health condition.
- Don’t drive or operate machinery after taking Combutol 400 mg, as it may cause mild side effects such as disorientation, dizziness, or tingling/numbness.
- Don’t take COMBUTOL 400 mg if you are allergic to Ethambutol or any of the other components of this tablet.
Combutol 400mg is an essential anti-tuberculosis drug used in the treatment of Tuberculosis. This antibiotic medicine is prescribed to patients in combination with other antitubercular drugs. It works by stopping Mycobacterium tuberculosis from growing, hence eliminating the infection. Patients must follow the doctor’s given dose to ensure full recovery. Side effects of Combutol 400 mg are very mild but should be monitored in patients such as pregnant women or those who have kidney or liver problems.
FAQs
When is the best time to take Combutol 400mg?
Patients can take this medication as a single dose daily at the same time as directed by the doctor.
What should I do if I miss a dose?
If you have missed a dose of Combutol, take it as soon as possible. But, if it is already time to take the next dose, do not take an extra dose to compensate for the missed one.
Can I drink alcohol while taking Combutol 400mg?
Don’t consume alcohol while taking Combutol 400 mg tablet, as it can slow down the medicine’s effectiveness and lead to liver injury.
Where can I buy Combutol 400mg?
Combutol 400mg can be bought from reputable online pharmacies like Arrowmeds.com. But make sure that you have a valid prescription to buy this medicine.





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