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PDE5 inhibitors
Phosphodiesterase type-5 inhibitors (PDE5 inhibitors) are among the most commonly used treatments for erectile dysfunction (ED). Interestingly, their effectiveness in improving ED symptoms was discovered accidentally. Initially, researchers were studying Sildenafil citrate for treating conditions like angina and high blood pressure, but they soon noticed its positive impact on erectile function.
Erectile dysfunction is believed to be the most common form of sexual dysfunction in men, and its prevalence tends to increase with age. In fact, it’s estimated that between 30 to 50 million men in the United States are affected by this condition.
PDE5 inhibitors are now considered the first-line treatment for men experiencing ED. This condition typically occurs due to inadequate blood flow to the penis, making these medications highly effective in restoring sexual function.
Keep reading to learn more about how PDE5 inhibitors work, their benefits, and what you should know before using them.
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Varieties of PDE5 inhibitors
- Erectile dysfunction can be the outcome of physiological or psychological reasons.
- Plus, PDE5 inhibitors can only act on factors due to physiological reasons.
- However, treatments for psychological reasons are counseling or psychotherapy.
- Additionally, this treatment of psychological factors treats anxiety or stress.
- Furthermore, the 4 chief kinds of PDE5 inhibitors in the market are:
- Avanafil (Stendra)
- Vardenafil (Levitra or Staxyn)
- Tadalafil (Cialis)
- Sildenafil (Viagra)
- Let you know about these PDE5 inhibitors one by one.
Sildenafil (Viagra)
- Sildenafil citrate was the initial PDE5 inhibitor.
- Also, on this PDE5 inhibitor, researchers worked more extensively.
- Moreover, the FDA certified it for ED treatment in 1998.
- Besides, the salt hit the market under the brand name Viagra to heal ED issues.
- Sildenafil is the active ingredient in Cenforce 100 and Fildena 100. It is in a category of medicines called Phosphodiesterase type 5 (PDE 5) inhibitors.
- Plus, Sildenafil normally starts its path of action in sixty minutes.
- Additionally, akin to other PDE5 inhibitors, a user can merely acquire an erection when he goes through a sensual stimulus.
For how time does it hold your system
- The terrific effects of this salt continue for nearly four hours.
- However, it can stay in the system for twelve hours.
- Furthermore, the typical dosage of the drug is between 25mg to 100mg each day.
Widespread side effects
The side effects are vision issues, cold-like symptoms, nasal congestion, indigestion, flushing, headaches, etc.
Cost
- The exact rate of Sildenafil differs from place to place.
- Also, the branded Viagra sells for above fifty dollars.
- Nevertheless, for three years, Sildenafil has been sold under different names and generic variants.
- However, generic variants are more cost-effective than Viagra.
Tadalafil (Cialis)
- Tadalafil salt came into the market in 2003 for the treatment of the ED problem.
- Plus, this salt takes merely twenty minutes to start an action.
- Additionally, a patient must ingest Tadalafil nearly 30 minutes prior to sensual interaction.
- Furthermore, the great effects of Tadalafil continue for 36 hours.
- Besides, this drug has FDA approval for curing benign prostatic hyperplasia.
For how time does it hold your system
- The salt of Tadalafil enjoys the quality of the longest period of action in comparison to any other PDE5 inhibitor.
- Vidalista is also an effective medicine of tadalafil.
- Also, you can eat it at a daily dose of 2.5mg to 5mg or sometimes 20mg.
Widespread side effects
- The side effects are muscle pain, cold-like symptoms, back pain, and nasal congestion.
- Besides, indigestion, flushing, and headache can occur.
Cost
- The rates of Cialis differ from one pharmacy to another and rely on the potency of the drug you are purchasing.
- Moreover, high doses like 20mg pills sell for nearly seventy dollars.
- Plus, the pills Cialis have generic brands and variants that sell at cheap rates.
- The side effects are muscle pain, cold-like symptoms, back pain, and nasal congestion.
- Besides, indigestion, flushing, and headache can occur.
Vardenafil (Levitra or Staxyn)
- For the management of ED, Vardenafil has been on the shelves since 2003.
- Additionally, this ED-curing salt possesses the shortest period of starting an action than other PDE5 inhibitors.
- Furthermore, the action begins within the period of ten minutes.
For how time does it hold your system
- The Vardenafil pills normally stay in the system for five to seven hours.
- However, Vardenafil can linger in your system for twelve hours.
- Also, the normal dosage of Vardenafil is five mg to twenty mg each day.
Widespread side effects
- The side effects are vision woes, cold-like symptoms, nasal congestion, indigestion, flushing, and headaches.
Cost
- Staxyn pills are more cost-effective than the pills of Levitra.
- Besides, a user has to dole out nearly the sum of forty dollars for each pill.
- However, the drug possesses generic variants too.
Avanafil (Stendra)
- The salt Avanafil is the latest one in the tally of PDE5 inhibitors available for use by the ED victims.
- Plus, since 2012, the salt has provided benefits to ED sufferers.
- Additionally, the amazing effects of Avanafil salt commence the action in 30-45 minutes.
For how time does it hold your system
- The salt Avanafil possesses an extended period of effect in comparison to Sildenafil & Vardenafil.
- Nevertheless, this period does not surpass the salt Tadalafil. Avanafil possesses a half-life of about five hours.
- Furthermore, the dosage of the salt is 50-200 milligrams each day.
Widespread side effects
- The side effects are cold-like signs, nasal congestion, indigestion, flushing, and headache.
Cost
- The pills of Avanafil 100 are sold for above seventy dollars each pill of 100 milligrams.
- However, rates vary between medical shops.
- Moreover, at present, Avanafil has no generic variant available in the market.
PDE5 inhibitors function
- PDE5 inhibitors show a vasodilation influence on your phallus.
- Plus, this means they assist the blood vessels to unwind and amplify blood volume towards the member.
The mechanism behind your erection
- The method of attaining an erection is intricate.
- Additionally, whenever a user experiences sensual stimulation, their parasympathetic nervous system turns on.
- Furthermore, this neural action gives rise to the liberation of a substance famous as nitric oxide.
- Also, this molecule augments the synthesis of another substance eminent as cyclic GMP.
- Besides, Cyclic GMP calms down the smooth muscles within your blood vessels of the phallus.
- Moreover, it increases blood supply nearly twenty to forty times towards the member.
- Plus, a chemical PDE5 breaks down cyclic GMP and stops the process of erection.
- Nevertheless, PDE5 inhibitors happen to be the same in makeup to cyclic GMP and attach to PDE5 to hinder this annihilation.
- Additionally, the activity of the PDE5 inhibitors enhances the activity of nitric oxide.
- Furthermore, it assists in encouraging a huge blood supply to the phallus.