Alternative Medicine

Oestrogel 80 g (Estradiol)

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Estrabet Gel (Estradiol)

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Progynova (Estradiol)

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Progynova 1 mg (Estradiol)

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Just $0.89 /Tablet View Detail This product has multiple variants. The options may be chosen on the product page

Description

What is Progynova 2 mg?

Progynova 2 mg is an oral contraceptive in tablet form that contains estradiol, a type of estrogen. This medication is often used as hormone replacement therapy (HRT) to treat menopause or other estrogen related conditions. It can also be used to treat symptoms of low estrogen and hormonal imbalances.

The drug Progynova is manufactured by a noted pharmaceutical company called Bayer Zydus Pharma, whose drugs are sold across the world in many countries.

Composition and Strength

Progynova contains estradiol, a synthetic form of estrogen. Estradiol, which helps stabilize Progynova for oral administration and is commonly used in hormone replacement therapy (HRT).

Estradiol was first isolated in 1935 by German scientist Adolf Butenandt, who was awarded the Nobel Prize in Chemistry in 1939 for his work on sex hormones. Since then, estradiol has become a key ingredient in many medications used to treat estrogen-related disorders.

Progynova tablets are available in two common strengths:

• Progynova 1 mg
• Progynova 2 mg

In some countries, Progynova is also available as a cream for the localized treatment of vaginal atrophy.

Indications and Uses

Progynova 2 mg is primarily used as Hormone Replacement Therapy (HRT) and treats other symptoms that arise due to estrogen deficiency. Some of its indications and uses are mentioned below:

• Prevention of osteoporosis: Applicable in women with postmenopausal symptoms as they experience bone reabsorption rendering them susceptible to fractures. Estradiol helps maintain bone density by inhibiting bone resorption.
• Menopausal symptoms relief: Such as mood swings, night sweats, vaginal dryness, and hot flashes are treated with the help of Progynova 2 mg.
• Hormone Replacement Therapy (HRT): Women with hysterectomy tend to suffer from estrogen deficiency; in such cases, Progynova 2 mg with its active ingredient Estradiol helps optimally maintain estrogen levels and treat estrogen deficiency.
• Transgender hormone therapy: Used in transgender women as a part of feminizing hormone therapy, thereby promoting the development of female characteristics such as breast development and skin softening.
• Accelerate puberty: in girls who are experiencing estrogen deficiency.
• Amenorrhea (absence of menstruation): Estradiol restores the normal level of estrogen and alleviates symptoms such as amenorrhea.
• Used to regulate irregular menstrual cycles, especially in women suffering from hormonal imbalance.

Mechanism of Action

Progynova 2 mg contains Estradiol Valerate, which when consumed in tablet form gets absorbed in the GI tract and undergoes hydrolysis in the liver into 17(beta)-estradiol, the primary bioactive form of estrogen. This primary bioactive form of estrogen then binds to estrogen receptors. Estradiol-bound estrogen receptors act as transcription factors, meaning they control the expression of specific genes, resulting in the synthesis of proteins that mediate the effects of estrogen. This is how Progynova 2 mg mimics the effects of natural estrogen.

Progynova 2 mg works efficiently in maintaining hormonal balance in the body, helping to alleviate various estrogen-deficiency symptoms.

Dosage and Administration

Administration

• It can be taken with or without food, but preferable to take it along with water.
• For a sustainable result, take the tablet at the same time every day.
• Do not chew or break the tablet; it is to be swallowed.

Dosage

The recommended dosage of Progynova will vary depending on the treatment. For example, the dosage used to treat menopausal symptoms may be different from the dosage used in gender-affirming therapy. People with impaired liver or kidney function may also require dosage adjustments, so be sure to consult your doctor before changing your dosage. Sometimes Progynova 2 mg is used as part of a cyclical treatment regimen, where you take it on a specific day and then take it off.

Missed dose: Upon missing a dose, avoid compensating by taking extra tablets in the next dose. Instead, take the next dose as recommended on time.

Overdose:  This can lead to unintended results, the consequences of which can be detrimental; hence, it is strictly recommended to adhere to the prescribed dosage.

Contraindications and Warnings

• Caution is to be exercised when patients with heart and liver symptoms take Progynova 2 mg.
• It is not to be used by pregnant women.
• In the case of breastfeeding women, this drug is not recommended.
• To be avoided by breast cancer patients.
• Patients with a history of thromboembolic disorders (blood clotting disorders) should avoid using Progynova 2 mg.
• Progynova 2mg should be discontinued if unexplained vaginal bleeding occurs.

Side Effects of Progynova 2 mg

Common side effects include:

• Nausea, headache, breast tenderness
• Vomiting, dizziness, skin rash.
• Bloating, weight changes, mood swings.

Rare but serious side effects include:

• Allergic reactions
• Heart failure
• Liver toxicity
• Increased risk of gallbladder disease in long-term users of Progynova 2 mg.
• Some women may experience visual disturbances such as blurred vision.

Drug Interactions

Progynova 2 mg with its active ingredient Estradiol is known to react with a range of drugs, hence when taking such drugs along with Progynova 2 mg, a physician’s advice is mandatory. Below are some of the interacting drugs:

• Thyroid Hormones (Levothyroxine): Estradiol interacts with Thyroid-binding free globulin (TBG), thereby reducing free T4 levels, which may cause hypothyroidism.
• Anticoagulants (Warfarin, Heparin, Apixaban): Estradiol promotes blood clotting; upon reacting with anticoagulants, Progynova 2 mg can reduce the effectiveness of blood thinners and increase blood clots.
• Diabetes Medications (Metformin, Insulin): Estradiol increases blood sugar levels and hence can reduce the effectiveness of diabetes-controlling medications.
• Corticosteroids (Prednisolone, Dexamethasone): Progynova 2 mg reduces corticosteroid metabolism, leading to higher water retention, higher blood pressure, and weight gain.
• Alcohol: Increases the side effects of Estradiol levels, thereby increasing risks of side effects such as headache, nausea, and blood clot risks.
• Other uses: It can be used in combination with progestin for endometrial protection in women with an intact uterus to prevent endometrial hyperplasia (overgrowth of the uterine lining).
• Certain antibiotics and antifungal medications may also affect the metabolism of Progynova 2 mg, altering its effectiveness.

Regular monitoring is required when Progynova 2 mg is being taken with interacting drugs as mentioned above.

Conclusion

Progynova 2 mg is a steroid that, when taken as prescribed and under the strict guidance of a physician, can yield satisfactory results leading to physical and mental well-being. Thus, making Progynova 2 mg the go-to drug option for achieving effective feminizing health. In addition to its benefits, it is vital to ensure that when Progynova 2 mg is prescribed in tandem with interacting drugs such as Metformin or Heparin, it is done so under the careful advice of the physician as the effectiveness and the efficacy of the drug can be affected. Progynova 2 mg plays a significant role in hormone regulation and should always be used with proper medical supervision.